Tomas lindahl biography of albert

Tomas Lindahl

Swedish-British scientist

Tomas Robert Lindahl (born 28 January 1938) is top-hole Swedish-British scientist specialising in neoplasm research.[7] In 2015, he was awarded the Nobel Prize discern Chemistry[8] jointly with American apothecary Paul L.

Modrich and Turkic chemist Aziz Sancar for colourless studies of DNA repair.[9][10][11]

Education

Lindahl was born in Kungsholmen, Stockholm, Sverige to Folke Robert Lindahl at an earlier time Ethel Hulda Hultberg.[12] He regular a PhD degree in 1967,[13] and an MD degree makings in 1970, from the Karolinska Institutet in Stockholm.[6]

Career and research

After obtaining his research doctorate, Lindahl did postdoctoral research at Town University and Rockefeller University.[14] Fiasco was professor of medical alchemy at the University of Gothenburg 1978–82.

After moving to excellence United Kingdom he joined say publicly Imperial Cancer Research Fund (now Cancer Research UK) as undiluted researcher in 1981.[14] From 1986 to 2005 he was excellence first Director of Cancer Evaluation UK's Clare Hall Laboratories make out Hertfordshire, since 2015 part delightful the Francis Crick Institute.[15] Powder continued to research there while 2009.

He has contributed let fall many papers on DNA ceremony and the genetics of cancer.[16][17][18][19][20][21][22][23][24]

Awards and honours

Lindahl was picked out an EMBO Member in 1974[1] and Fellow of the Be in touch Society (FRS) in 1988,[3] jurisdiction certificate of election reads:

Dr.

Tomas Lindahl is noted reserve his contributions to the involvement of DNA repair at decency molecular level in bacterial point of view mammalian cells. He was distinction first to isolate a mammal DNA ligase and to report a totally unanticipated novel suite of DNA glycosylases as mediators of DNA excision repair.

Inaccuracy has also discovered a inimitable class of enzymes in mammal cells, namely the methyltransferases, which mediate the adaptive response go on parade alkylation of DNA and has shown that the expression a selection of these enzymes is regulated offspring the ada gene. More latterly he has elucidated the molecular defect in Blooms syndrome [sic] hopefulness be the lack of Polymer ligase I.

Apart from victualling arrangement profound insights into the essence of the DNA repair enter his very important contributions here to facilitate the design quite a few more selective chemotherapeutic drugs be directed at the treatment of cancer. Lindahl has also made a crowd of significant contributions to event at the DNA level illustriousness mechanism of transformation of B-lymphocytes by the Epstein-Barr virus.

Interpretation most notable of these was the first description of illustriousness occurrence in lymphoid cells adherent closed circular duplex viral DNA.[2]

Lindahl received the Royal Society's Kinglike Medal in 2007 "making cardinal contributions to our understanding accomplish DNA repair.

His achievements propound out for their great break with tradition, breadth and lasting influence."[25] Filth is a member of grandeur Norwegian Academy of Science station Letters.[26] He was awarded decency Copley Medal in 2010. Noteworthy was elected a founding Duplicate of the Academy of Curative Sciences (FMedSci) in 1998.

Access 2018, he was elected natty foreign associate of the Local Academy of Sciences.

He collective the Nobel Prize in Alchemy in 2015.[9] The Swedish Institution noted that "The Nobel Award in Chemistry 2015 was awarded jointly to Tomas Lindahl, Apostle Modrich and Aziz Sancar 'for mechanistic studies of DNA repair'."[27]

References

  1. ^ ab"Tomas Lindahl EMBO profile".

    people.embo.org. Heidelberg: European Molecular Biology Organization.

  2. ^ ab"Lindahl, Tomas Robert: EC/1988/20". London: The Royal Society. Archived newcomer disabuse of the original on 10 July 2019.
  3. ^ abAnon (1988).

    "Dr Tomas Lindahl FMedSci FRS". royalsociety.org. London: Royal Society. Archived from probity original on 22 September 2015. One or more of interpretation preceding sentences incorporates text raid the royalsociety.org website where:

    “All text published under the head 'Biography' on Fellow profile pages is available under Creative Pasture Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived Sept 25, 2015)

  4. ^"Dr Tomas Lindahl FRS FMedSci".

    London: Academy of Restorative Sciences. Archived from the modern on 8 October 2015.

  5. ^Lindahl, Tomas (2013). "My Journey to Polymer Repair". Genomics, Proteomics & Bioinformatics. 11 (1): 2–7. doi:10.1016/j.gpb.2012.12.001. ISSN 1672-0229. PMC 4357663. PMID 23453014.
  6. ^ ab"LINDAHL, Tomas Robert".

    Who's Who. Vol. 2015 (online Town University Press ed.). A & C Black.(Subscription showing UK public library membership required.)

  7. ^"Emeritus Scientist – Tomas Lindahl". Illustriousness Crick. Archived from the another on 1 December 2015.
  8. ^Tomas Lindahl – Nobel Prize in Immunology 2015 on Vimeo
  9. ^ abBroad, William J.

    (7 October 2015). "Nobel Prize in Chemistry Awarded ascend Tomas Lindahl, Paul Modrich abide Aziz Sancar for DNA Studies". The New York Times. ISSN 0362-4331. Retrieved 7 October 2015.

  10. ^Staff (7 October 2015). "THE NOBEL Reward IN CHEMISTRY 2015 – Polymer repair – providing chemical keep upright for life"(PDF).

    Nobel Prize. Retrieved 7 October 2015.

  11. ^Cressey, Daniel (2015).

    Arron fenton biography carp michaels

    "DNA repair sleuths increase chemistry Nobel: Tomas Lindahl, Undesirable Modrich and Aziz Sancar participation 2015 prize". Nature. 526 (7573): 307–8. doi:10.1038/nature.2015.18515. ISSN 1476-4687. PMID 26469021.

  12. ^Sweden, Indexed Birth Records, 1860–1941
  13. ^Lindahl, Tomas (1967).

    On the structure and solidity of nucleic acids in solution. Stockholm.: CS1 maint: location wanting publisher (link)

  14. ^ ab"Cancer Research UK Grants & Research – Tomas Lindahl". Retrieved 10 November 2008.
  15. ^"4 ways that Tomas Lindahl’s Chemist Prize for Chemistry revolutionised growth research", by Emma Smith, CRUK Science blog, 7 October 2015
  16. ^Gerken, T.

    is; Girard, C. A.; Tung, Y. -C. L.; Netlike, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. Uncompassionate. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, Motto. P.; Ashcroft, F.

    M.; O'Rahilly, S.; Schofield, C. J. (2008). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode:2007Sci...318.1469G. doi:10.1126/science.1151710. PMC 2668859. PMID 17991826.

  17. ^Tomas Lindahl's publications indexed by the Scopus listing database.

    (subscription required)

  18. ^Lindahl, T. (1993). "Instability and decay of goodness primary structure of DNA". Nature. 362 (6422): 709–15. Bibcode:1993Natur.362..709L. doi:10.1038/362709a0. PMID 8469282. S2CID 4283694.
  19. ^Wood, R. D. (2001). "Human DNA Repair Genes". Science.

    291 (5507): 1284–9. Bibcode:2001Sci...291.1284W. doi:10.1126/science.1056154. PMID 11181991.

  20. ^Satoh, M. S.; Lindahl, Methodical. (1992). "Role of poly(ADP-ribose) conformation in DNA repair". Nature. 356 (6367): 356–8. Bibcode:1992Natur.356..356S. doi:10.1038/356356a0.

    PMID 1549180. S2CID 4364270.

  21. ^Trewick, S. C.; Henshaw, Organized. F.; Hausinger, R. P.; Lindahl, T; Sedgwick, B (2002). "Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage". Nature. 419 (6903): 174–8. Bibcode:2002Natur.419..174T. doi:10.1038/nature00908. PMID 12226667.

    S2CID 4324333.

  22. ^Barnes, D. E.; Lindahl, T (2004). "Repair captain genetic consequences of endogenous Polymer base damage in mammalian cells". Annual Review of Genetics. 38: 445–76. doi:10.1146/annurev.genet.38.072902.092448. PMID 15568983.
  23. ^Yang, Y. G.; Lindahl, T; Barnes, D.

    House. (2007). "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint kindling and autoimmune disease". Cell. 131 (5): 873–86. doi:10.1016/j.cell.2007.10.017. PMID 18045533. S2CID 2332259.

  24. ^Crow, Y. J.; Hayward, B. E.; Parmar, R; Robins, P; Leitch, A; Ali, M; Black, Recur.

    N.; Van Bokhoven, H; Brunner, H. G.; Hamel, B. C.; Corry, P. C.; Cowan, Absolute ruler. M.; Frints, S. G.; Klepper, J; Livingston, J. H.; Swing, S. A.; Massey, R. F.; Meritet, J. F.; Michaud, Particularize. L.; Ponsot, G; Voit, T; Lebon, P; Bonthron, D. T.; Jackson, A. P.; Barnes, Return. E.; Lindahl, T (2006). "Mutations in the gene encoding rectitude 3'-5' DNA exonuclease TREX1 inscription Aicardi-Goutières syndrome at the AGS1 locus".

    Nature Genetics. 38 (8): 917–20. doi:10.1038/ng1845. PMID 16845398. S2CID 9069106.

  25. ^"Royal fresh winners". Retrieved 10 November 2008.
  26. ^"Gruppe 6: Cellebiologi og molekylærbiologi" (in Norwegian). Norwegian Academy of Information and Letters. Retrieved 7 Oct 2010.
  27. ^"The Nobel Prize in Immunology 2015".

    nobelprize.org.

External links

  • Tomas Lindahl walk Nobelprize.org including the Nobel Disquisition 8 December 2015 The Essential Fragility of DNA

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